HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone → 6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Reactant | 6-Bromo-5-hydroxy-1H-indole-2-carboxylic acid ethyl ester | HCID 67017907 | — |
| Product | 6-Bromo-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 67017929 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of intermediate 1, step 2, the title compound was synthesized from 6-bromo-5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (example 41, step 3). The title compound was obtained in 56% yield as light yellow solid. MS (m/e): 409.0 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-0b4f611ff9884dfea65226c4b750e0d2 |
| Source note | uspto-grants-2010_06 |