Ethyl trifluoroacetate → HCID 15540009, compound

HRID 1988509Notes

Reaction equation

HRID 1988509 reaction equation
[NH2:1][CH:2]([CH2:5][OH:6])[CH2:3][OH:4].[F:7][C:8]([F:15])([F:14])[C:9](OCC)=[O:10]>O1CCCC1>[F:7][C:8]([F:15])([F:14])[C:9]([NH:1][CH:2]([CH2:5][OH:6])[CH2:3][OH:4])=[O:10]

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 68294Serinol

Product 1

HCID 15540009HCID 15540009, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

4 g of 2-aminopropan-1,3-diol (43.9 mmol) were supplemented with 20 ml of tetrahydrofuran. The reaction mixture was then cooled to 0° C. on an ice bath and 5.8 ml of ethyl trifluoroacetate (48.3 mmol) were gradually added. This solution was stirred for 2 hours at room temperature.

Sources & evidence

ORD record
ord-5aad3ba693fa461388b4f74e941c3597
Source dataset
uspto-grants-2010_01
Patent number
US07641914B2

Reaction notes

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