3-Amino-1-propanol → HCID 60678886, compound
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].Br[CH2:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]>ClCCl>[C:11]([O:10][C:8](=[O:9])[CH2:7][NH:1][CH2:2][CH2:3][CH2:4][OH:5])([CH3:14])([CH3:13])[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
196 ml of 3-aminopropanol (2.56 mol) were diluted in 250 ml of dichloromethane and the whole was cooled to 0° C. on an ice bath. 20 g of tert-butyl bromoacetate (102.5 mmol), solubilized in 200 ml of dichloromethane, were then added dropwise while the reaction mixture was maintained at 0° C. At the end of the addition (2 hours later), the reaction mixture was left at room temperature for 3 hours.
Workup
- additionwere then added dropwise while the reaction mixture
- temperaturewas maintained at 0° C
- additionAt the end of the addition (2 hours later), the reaction mixture
Sources & evidence
- ORD record
- ord-86bcf6711224445d83ebc4764cf33657
- Source dataset
- uspto-grants-2010_01
- Patent number
- US07641914B2
Reaction notes
Loading…