Triethylamine → HCID 86597569, compound

HRID 1988513Notes

Reaction equation

HRID 1988513 reaction equation
C(N(CC)CC)C.[F:8][C:9]([F:42])([F:41])[C:10]([NH:12][CH2:13][CH2:14][CH2:15][N:16]([CH2:31][CH2:32][CH2:33][NH:34][C:35](=[O:40])[C:36]([F:39])([F:38])[F:37])[CH2:17][CH2:18][CH2:19][N:20]([CH2:27][C:28](O)=[O:29])[C:21](=[O:26])[C:22]([F:25])([F:24])[F:23])=[O:11].F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.[NH2:70][CH2:71][CH:72]1[CH2:76][O:75][CH:74]([O:77][CH2:78][CH2:79][CH2:80][C:81]([N:83]([CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH2:104][CH2:105][CH2:106][CH2:107][CH2:108][CH2:109][CH2:110][CH3:111])[CH2:84][CH2:85][CH2:86][CH2:87][CH2:88][CH2:89][CH2:90][CH2:91][CH2:92][CH2:93][CH2:94][CH2:95][CH2:96][CH3:97])=[O:82])[O:73]1>ClCCl>[F:8][C:9]([F:41])([F:42])[C:10]([NH:12][CH2:13][CH2:14][CH2:15][N:16]([CH2:31][CH2:32][CH2:33][NH:34][C:35](=[O:40])[C:36]([F:37])([F:38])[F:39])[CH2:17][CH2:18][CH2:19][N:20]([C:21](=[O:26])[C:22]([F:24])([F:25])[F:23])[CH2:27][C:28]([NH:70][CH2:71][CH:72]1[CH2:76][O:75][CH:74]([O:77][CH2:78][CH2:79][CH2:80][C:81]([N:83]([CH2:98][CH2:99][CH2:100][CH2:101][CH2:102][CH2:103][CH2:104][CH2:105][CH2:106][CH2:107][CH2:108][CH2:109][CH2:110][CH3:111])[CH2:84][CH2:85][CH2:86][CH2:87][CH2:88][CH2:89][CH2:90][CH2:91][CH2:92][CH2:93][CH2:94][CH2:95][CH2:96][CH3:97])=[O:82])[O:73]1)=[O:29])=[O:11]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 17957565HCID 17957565, compoundHCID 86597570HCID 86597570, compound

Product 1

HCID 86597569HCID 86597569, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.9 ml of triethylamine (13.8 mmol), 2 g of [(3-{bis[3-(2,2,2-trifluoroacetylamino)propyl]amino}-propyl)trifluoroacetylamino]acetic acid (trifluoroacetate salt, 3.04 mmol) and 1.8 g of BOP (4.14 mmol) were successively added to 1.65 g of 4-(4-aminomethyl-[1,3]dioxolan-2-yloxy)-N,N-ditetradecylbutyramide (2.76 mmol) dissolved in 30 ml of dichloromethane. The solution was stirred for 1 hour at room temperature.

Sources & evidence

ORD record
ord-9c0886e36b6c45b380282aacb796097a
Source dataset
uspto-grants-2010_01
Patent number
US07641914B2

Reaction notes

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