Sodium Hydroxide → HCID 59126085, compound

HRID 1988514Notes

Reaction equation

HRID 1988514 reaction equation
FC(F)(F)C([NH:5][CH2:6][CH2:7][CH2:8][N:9]([CH2:65][CH2:66][CH2:67][NH:68]C(=O)C(F)(F)F)[CH2:10][CH2:11][CH2:12][N:13](C(=O)C(F)(F)F)[CH2:14][C:15]([NH:17][CH2:18][CH:19]1[CH2:23][O:22][CH:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]([N:30]([CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])=[O:29])[O:20]1)=[O:16])=O.[OH-].[Na+]>O1CCCC1>[NH2:5][CH2:6][CH2:7][CH2:8][N:9]([CH2:65][CH2:66][CH2:67][NH2:68])[CH2:10][CH2:11][CH2:12][NH:13][CH2:14][C:15]([NH:17][CH2:18][CH:19]1[CH2:23][O:22][CH:21]([O:24][CH2:25][CH2:26][CH2:27][C:28]([N:30]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58])=[O:29])[O:20]1)=[O:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86597569HCID 86597569, compound

Product 1

HCID 59126085HCID 59126085, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.1 g of 4-[4-({2-[(3-{bis[3-(2,2,2-trifluoroacetylamino)propyl]amino}propyl)trifluoro-acetylamino]acetylamino}methyl)-[1,3]dioxolan-2-yloxy]-N,N-ditetradecylbutyramide (1.88 mmol) were dissolved in 30 ml of tetrahydrofuran, and 30 ml of molar sodium hydroxide at 4% were added, with vigorous stirring. The reaction was left overnight at room temperature.

Sources & evidence

ORD record
ord-a3ca8e87ca9749dba217402ba939dfe8
Source dataset
uspto-grants-2010_01
Patent number
US07641914B2

Reaction notes

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