Water → 6-Chloro-N-[2-(2,4-dichlorophenyl)ethyl]-2-methoxy-4-pyrimidinamine

HRID 1988565Notes

Reaction equation

HRID 1988565 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([O:9][CH3:10])[N:3]=1.[Cl:11][C:12]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:13]=1[CH2:14][CH2:15][NH2:16].C(=O)(O)[O-].[Na+].O>C(O)C>[Cl:8][C:6]1[N:5]=[C:4]([O:9][CH3:10])[N:3]=[C:2]([NH:16][CH2:15][CH2:14][C:13]2[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:12]=2[Cl:11])[CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 1429382,4-DichlorophenethylamineHCID 516892Sodium BicarbonateHCID 120521604,6-Dichloro-2-methoxypyrimidine

Product 1

HCID 576360046-Chloro-N-[2-(2,4-dichlorophenyl)ethyl]-2-methoxy-4-pyrimidinamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4,6-dichloro-2-methoxypyrimidine (0.7 g), 2,4-dichlorophenethylamine (0.82 g) and sodium bicarbonate (0.88 g) in ethanol (25 mL) is heated at 80° C. for three hours and poured into water (400 mL). The resulting solid is filtered and air dried to afford (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2,4-dichloro-phenyl)-ethyl]-amine.

Workup

  1. filtrationThe resulting solid is filtered
  2. customair dried

Sources & evidence

ORD record
ord-265dde84257f422fb31da79c977479ea
Source dataset
uspto-grants-2010_01
Patent number
US07642249B2

Reaction notes

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