Piperonyl alcohol → 4-[(2H-1,3-Benzodioxol-5-yl)methoxy]-3-nitropyridine

HRID 1988840Notes

Reaction equation

HRID 1988840 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH2:11]([OH:21])[C:12]1[CH:20]=[CH:19][C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=1>>[O:17]1[C:18]2[CH:19]=[CH:20][C:12]([CH2:11][O:21][C:2]3[CH:7]=[CH:6][N:5]=[CH:4][C:3]=3[N+:8]([O-:10])=[O:9])=[CH:13][C:14]=2[O:15][CH2:16]1

Participants

3

Reactant 2

HCID 10322Piperonyl alcoholHCID 27357814-Chloro-3-nitropyridine

Product 1

HCID 687024964-[(2H-1,3-Benzodioxol-5-yl)methoxy]-3-nitropyridine

Procedure

In accordance with the same procedures as in Preparation 2, except for using 4-chloro-3-nitropyridine (3.0 g, 18.92 mmol) prepared in Step 1 of Preparation 1 and piperonyl alcohol (3.45 ml, 18.92 mmol), the titled compound was obtained as a yellow solid. (3.08 g, 88.6%)

Workup

  1. customIn accordance with the same procedures as in Preparation 2

Sources & evidence

ORD record
ord-fe6f388fe6c44081b5017dae111c3eac
Source dataset
uspto-grants-2010_01
Patent number
US07642269B2

Reaction notes

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