4-(Trifluoromethyl)benzenemethanol → 3-Nitro-4-{[4-(trifluoromethyl)phenyl]methoxy}pyridine

HRID 1988848Notes

Reaction equation

HRID 1988848 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[F:11][C:12]([F:22])([F:21])[C:13]1[CH:20]=[CH:19][C:16]([CH2:17][OH:18])=[CH:15][CH:14]=1>>[F:11][C:12]([F:21])([F:22])[C:13]1[CH:20]=[CH:19][C:16]([CH2:17][O:18][C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 676844-(Trifluoromethyl)benzenemethanolHCID 27357814-Chloro-3-nitropyridine

Product 1

HCID 687064313-Nitro-4-{[4-(trifluoromethyl)phenyl]methoxy}pyridineYield 89.5%

Procedure

In accordance with the same procedures as in Preparation 2, except for using 4-chloro-3-nitropyridine prepared in Step 1 of Preparation 1 and 4-trifluoromethylbenzyl alcohol, the titled compound was obtained as a yellow solid. (Yield: 89.5%)

Workup

  1. customIn accordance with the same procedures as in Preparation 2

Sources & evidence

ORD record
ord-09b6b3d025c3449f9d3634eddb89acd4
Source dataset
uspto-grants-2010_01
Patent number
US07642269B2

Reaction notes

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