Morpholine → 4-(3-Nitrophenyl)morpholine

HRID 1988873Notes

Reaction equation

HRID 1988873 reaction equation
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[N+:8]([C:4]1[CH:3]=[C:2]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 98231-Fluoro-3-nitrobenzene

Product 1

HCID 12532734-(3-Nitrophenyl)morpholine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
110 °C

Procedure

3-Fluoronitrobenzene (10 g) was added to a solution of morpholine (34 ml) in DMSO (120 ml) and heated at 110° C. for 60 h. The reaction mixture was cooled and poured onto water (800 ml). The precipitate was collected by filtration and the orange solid was dried under vacuum and used in subsequent reactions without further purification (13.7 g).

Workup

  1. temperatureThe reaction mixture was cooled
  2. additionpoured onto water (800 ml)
  3. filtrationThe precipitate was collected by filtration
  4. customthe orange solid was dried under vacuum
  5. customused in subsequent reactions without further purification (13.7 g)

Sources & evidence

ORD record
ord-27666ccd2c024e3896941b50b9d0517a
Source dataset
uspto-grants-2010_01
Patent number
US07642276B2

Reaction notes

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