Morpholine → 4-(3-Nitrophenyl)morpholine

Participants

Reaction Conditions

Reaction Steps

3-Fluoronitrobenzene (10 g) was added to a solution of morpholine (34 ml) in DMSO (120 ml) and heated at 110° C. for 60 h. The reaction mixture was cooled and poured onto water (800 ml). The precipitate was collected by filtration and the orange solid was dried under vacuum and used in subsequent reactions without further purification (13.7 g).

Provenance & Evidence