反应详情

A solution of methyl 4-bromo-2-hydroxybenzoate (Intermediate 22) (0.7 g) in dioxan (5 ml) was added dropwise to a solution of hydroxylamine hydrochloride (0.32 g) and sodium hydroxide (0.42 g) in water (10 ml) then stirred at room temp. for 18 h. The dioxan was removed under vacuum and the residue was stirred with 2N hydrochloric acid to give a precipitate which was collected by filtration, washed with water and dried to give the title compound as an off-white solid (0.63 g).

1. customThe dioxan was removed under vacuum
2. stirringthe residue was stirred with 2N hydrochloric acid
3. customto give a precipitate which
4. filtrationwas collected by filtration
5. washwashed with water
6. customdried