反应详情

A solution of ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate (Intermediate 30) (2.0 g) in dry toluene (20 ml) was stirred at reflux under nitrogen for 24 h. On cooling the resulting precipitate was collected by filtration, washed with ether and dried to give the title compound as a white solid (1.32 g).

1. temperatureat reflux under nitrogen for 24 h
2. temperatureOn cooling the resulting precipitate
3. filtrationwas collected by filtration
4. washwashed with ether
5. customdried