HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate → 7-Bromo-4-hydroxycoumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate | HCID 59127384 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 7-Bromo-4-hydroxycoumarin | HCID 54696229 | 78.6% |
Reaction Steps
A solution of ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate (Intermediate 30) (2.0 g) in dry toluene (20 ml) was stirred at reflux under nitrogen for 24 h. On cooling the resulting precipitate was collected by filtration, washed with ether and dried to give the title compound as a white solid (1.32 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642276B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-ca540a040e4345979095e68bbca15e30 |
| Source note | uspto-grants-2010_01 |