反应详情

Sodium tert-butoxide (0.057 g) was added to an ice-cold solution of 6-bromo-3-(methylsulfonyl)-1H-indazole (Intermediate 75) (0.14 g) in tetrahydrofuran (1.5 ml). 2-(Trimethylsilyl)ethoxymethyl chloride (0.11 ml) was then added and the mixture was warmed to room temp. over 1 h. The reaction was quenched using 2M aqueous ammonia (1 ml) and methanol (1 ml) the solvent was evaporated and the aqueous residue was extracted with ethyl acetate. The organic extracts were dried using a hydrophobic filter tube and concentrated under vacuum to give the title compound (0.67 g).

1. temperaturethe mixture was warmed to room temp. over 1 h
2. customThe reaction was quenched
3. customwas evaporated
4. extractionthe aqueous residue was extracted with ethyl acetate
5. customThe organic extracts were dried
6. concentrationconcentrated under vacuum