反应详情

A mixture of 2-[(6-bromo-1,2-benzisoxazol-3-yl)methyl]amino-1,3-propanediol (Intermediate 2, 8 mg), N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 5, 10 mg) aqueous sodium carbonate (1M, 0.1 ml) and tetrakis(triphenylphosphine)palladium(0) (1 mg) in 2-propanol (0.2 ml) was stirred at 80° under nitrogen for 18 h. The solvent was evaporated and the residue was purified on a Varian Bond-Elut SPE cartridge (silica, 500 mg) using a dichloromethane-methanol elution gradient (19:1 to 9:1) to give the title compound as an oil (3 mg).

1. customThe solvent was evaporated
2. customthe residue was purified on a Varian Bond-Elut SPE cartridge (silica, 500 mg)
3. washa dichloromethane-methanol elution gradient (19:1 to 9:1)