反应详情

A solution of 1,1-dimethylethyl 4-(6-{5-[(cyclopropylamino)carbonyl]-2methylphenyl}-1,2-benzisoxazol-3-yl)-1-piperazinecarboxylate (Intermediate 26) in methanol (1 ml) was treated with a solution of hydrogen chloride in dioxan (4N, 1 ml) then stirred at room temp. for 18 h. The solvent was evaporated and the residue was re-dissolved in methanol and applied to an SCX cartridge (1 g). Elution with methanol followed by methanol:0.88 ammonia (99:1) gave the title compound as a white solid (0.016 g).

1. customThe solvent was evaporated
2. dissolutionthe residue was re-dissolved in methanol
3. washElution with methanol