Hydrochloric Acid → N-Cyclopropyl-4-methyl-3-[1-(4-piperidinyl)-1H-indazol-5-yl]benzamide hydrochloride

HRID 1988934Notes

Reaction equation

HRID 1988934 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:35])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH:22]3[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]3)[N:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[ClH:36].CO>O1CCOCC1>[ClH:36].[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:8]=[CH:9][C:10]([CH3:35])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[N:17]=[CH:16]4)[CH:12]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 586565121,1-Dimethylethyl 4-(5-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-1H-indazol-1-yl)-1-piperidinecarboxylate

Product 1

HCID 68677201N-Cyclopropyl-4-methyl-3-[1-(4-piperidinyl)-1H-indazol-5-yl]benzamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of 1,1-dimethylethyl 4-(5-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-1H-indazol-1-yl)-1-piperidinecarboxylate Example 115) (0.01 g) in a solution of hydrogen chloride in dioxan (4M, 1 ml) was treated with methanol (0.25 ml) to give a solution which was stirred at room temp. for 18 h. The solvent was evaporated and the residue was dried under vacuum to give the title compound (0.009 g).

Workup

  1. customto give a solution which
  2. customThe solvent was evaporated
  3. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-cd36268755c9456cbfcae84049c00732
Source dataset
uspto-grants-2010_01
Patent number
US07642276B2

Reaction notes

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