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Conc. hydrochloric acid ((0.5 ml) was added to a solution of N-cyclopropyl-3-fluoro-4-methyl-5-[3-(methylsulfonyl)-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-indazol-6-yl]benzamide (Intermediate 77) (0.15 g) then stirred at reflux for 12 h. The solvent was evaporated and the residue was purified by column chromatography on silica, eluting with cyclohexane:ethyl acetate (1:1 to 1:2) to give the title compound (0.085 g).

1. temperatureat reflux for 12 h
2. customThe solvent was evaporated
3. customthe residue was purified by column chromatography on silica
4. washeluting with cyclohexane:ethyl acetate (1:1 to 1:2)