Propylamine → N-Cyclopropyl-3-fluoro-4-methyl-5-{1-[2-oxo-2-(propylamino)ethyl]-1H-indazol-5-yl}benzamide

HRID 1988952Notes

Reaction equation

HRID 1988952 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[C:9]([F:28])[C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23]([O:25]C)=O)[N:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH2:29]([NH2:32])[CH2:30][CH3:31]>>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23](=[O:25])[NH:32][CH2:29][CH2:30][CH3:31])[N:17]=[CH:16]4)[C:10]([CH3:27])=[C:9]([F:28])[CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7852PropylamineHCID 58656520HCID 58656520, compound

Product 1

HCID 58656523N-Cyclopropyl-3-fluoro-4-methyl-5-{1-[2-oxo-2-(propylamino)ethyl]-1H-indazol-5-yl}benzamide

Procedure

Example 136 was prepared by General Method D using methyl (5-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-1H-indazol-1-yl)acetate (Example 123) and 1-propylamine to give the title compound (0.005 g).

Workup

  1. customExample 136 was prepared by General Method D

Sources & evidence

ORD record
ord-a3ec99f9f3204a42b3ff470537583904
Source dataset
uspto-grants-2010_01
Patent number
US07642276B2

Reaction notes

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