Cyclopropanemethanamine → N-cyclopropyl-3-(1-{2-[(cyclopropylmethyl)amino]-2-oxoethyl}-1H-indazol-5-yl)-5-fluoro-4-methylbenzamide

HRID 1988953Notes

Reaction equation

HRID 1988953 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[C:9]([F:28])[C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23](OC)=[O:24])[N:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH:29]1([CH2:32][NH2:33])[CH2:31][CH2:30]1>>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:8]=[C:9]([F:28])[C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23]([NH:33][CH2:32][CH:29]3[CH2:31][CH2:30]3)=[O:24])[N:17]=[CH:16]4)[CH:12]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 58656520HCID 58656520, compound

Product 1

HCID 58656451N-cyclopropyl-3-(1-{2-[(cyclopropylmethyl)amino]-2-oxoethyl}-1H-indazol-5-yl)-5-fluoro-4-methylbenzamide

Procedure

Example 137 was prepared by General Method D using methyl (5-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-1H-indazol-1-yl)acetate (Example 123) and 1-cyclopropylmethanamine to give the title compound (0.008 g).

Workup

  1. customExample 137 was prepared by General Method D

Sources & evidence

ORD record
ord-9ca721f97cb2465b85c0c0aa3ce9b073
Source dataset
uspto-grants-2010_01
Patent number
US07642276B2

Reaction notes

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