Benzoyl chloride → HCID 135819949, compound

HRID 1988978Notes

Reaction equation

HRID 1988978 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:15]=[C:14]([C:16]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][C:23]=5[NH2:25])[NH:18][N:17]=4)[NH:13][C:12]=3[CH:26]=2)[CH2:4][CH2:3]1.[C:27](Cl)(=[O:34])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C(N(C(C)C)CC)(C)C>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:15]=[C:14]([C:16]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][C:23]=5[NH:25][C:27](=[O:34])[C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=5)[NH:18][N:17]=4)[NH:13][C:12]=3[CH:26]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 81531DiisopropylethylamineHCID 135820263HCID 135820263, compound

Product 1

HCID 135819949HCID 135819949, compound

Procedure

3-[6-(4-Methylpiperazin-1-yl)-1H-benzoimidazol-2-yl]-1H-indazol-4-ylamine as dissolved in CH2C2 and benzoyl chloride (1.1 equivalent) is added followed by diisopropylethylamine (1.1 equivalent). The resulting mixture is stirred overnight. The solution is then concentrated and the resulting residue is purified by preparatory HPLC to provide the title compound.

Workup

  1. additionis added
  2. concentrationThe solution is then concentrated
  3. customthe resulting residue is purified by preparatory HPLC

Sources & evidence

ORD record
ord-3fa05338dc424eda95bc0c41a945f0a1
Source dataset
uspto-grants-2010_01
Patent number
US07642278B2

Reaction notes

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