反应详情

9-Isopropyl-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one was dissolved in THF and LiA1H4 (5 equivalents) was added. The reaction was heated at reflux for 4 hours and then cooled to room temperature. NaF (20 equivalents) and water (5 equivalents) were added and the reaction was stirred vigorously for 1 hour. The resulting precipitate was filtered away and the filtrate was concentrated to provide the title compound as a colorless oil. GC/MS (m/z) 198, Rt=12.57 minutes.

1. additionLiA1H4 (5 equivalents) was added
2. temperatureThe reaction was heated
3. temperatureat reflux for 4 hours
4. filtrationThe resulting precipitate was filtered away
5. concentrationthe filtrate was concentrated