Hydrochloric Acid → HCID 19689240, compound

HRID 1989Notes

Reaction equation

HRID 1989 reaction equation
[CH2:1]([N:8]1[C:17](=[O:18])[C:16]2[N:15](COCC)[CH:14]=[N:13][C:12]=2[N:11]([CH3:23])[C:9]1=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24]>>[ClH:24].[CH2:1]([N:8]1[C:17](=[O:18])[C:16]2[NH:15][CH:14]=[N:13][C:12]=2[N:11]([CH3:23])[C:9]1=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 196892521-Benzyl-7-ethoxymethyl-3-methylxanthine

Product 1

HCID 19689240HCID 19689240, compound

Conditions

Temperature
60 °C

Procedure

The unpurified 1-benzyl-7-ethoxymethyl-3-methylxanthine was treated with 1000 ml of 5N hydrochloric acid and stirred at 60° C. for 6 hours. The precipitated solid was filtered off with suction, washed with ethanol and dried under reduced pressure (164 g). It was possible from the mother liquor, after concentrating to approximately 50%, to isolate a further 35 g of the desired product.

Workup

  1. filtrationThe precipitated solid was filtered off with suction
  2. washwashed with ethanol
  3. customdried under reduced pressure (164 g)
  4. concentrationafter concentrating to approximately 50%

Sources & evidence

ORD record
ord-3a7e91768d4c487cad45cb6ac939a6f7
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

Loading…