反应详情

温度

60 °C

The unpurified 1-benzyl-7-ethoxymethyl-3-methylxanthine was treated with 1000 ml of 5N hydrochloric acid and stirred at 60° C. for 6 hours. The precipitated solid was filtered off with suction, washed with ethanol and dried under reduced pressure (164 g). It was possible from the mother liquor, after concentrating to approximately 50%, to isolate a further 35 g of the desired product.

1. filtrationThe precipitated solid was filtered off with suction
2. washwashed with ethanol
3. customdried under reduced pressure (164 g)
4. concentrationafter concentrating to approximately 50%