Phosphorus oxychloride → HCID 4504275, compound

HRID 1989092Notes

Reaction equation

HRID 1989092 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[NH:11][C:10](=O)[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:10]1[N:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 120794684-(4-Chlorophenyl)-6-(trifluoromethyl)pyrimidin-2-ol

Product 1

HCID 4504275HCID 4504275, compound

Procedure

The title compound was prepared from 4-(4-chloro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (6.96 g, 25.3 mmol) and phosphoryl chloride (80 mL) according to the general procedure I. Obtained as an off-white solid (7.35 g, 99%). MS (EI) 292.0 [(M)+]; mp 108° C.

Sources & evidence

ORD record
ord-65995f131243477d8f942696c2a27ca6
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

Loading…