Phosphorus oxychloride → HCID 57468608, compound

HRID 1989096Notes

Reaction equation

HRID 1989096 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[NH:11][C:10](=O)[N:9]=2)=[CH:4][C:3]=1[CH3:19].P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:10]1[N:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH3:19])[CH:4]=2)[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 57468609HCID 57468609, compound

Product 1

HCID 57468608HCID 57468608, compound

Procedure

The title compound was prepared from 4-(4-chloro-3-methyl-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (9.07 g, 31.4 mmol) and phosphoryl chloride (100 mL) according to the general procedure I. Obtained as a white solid (8.68 g, 99%). MS (EI) 306.1 [(M)+]; mp 90° C.

Sources & evidence

ORD record
ord-c365f929ad204d07bbba0eaf35051575
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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