HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-trifluoromethyl-6-(4-trifluoromethylphenyl)-1H-pyridin-2-one | HCID 57468622 | — |
| Product | 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyridine | HCID 57468621 | — |
Reaction Steps
The title compound was prepared from 4-trifluoromethyl-6-(4-trifluoromethylphenyl)-1H-pyridin-2-one (51.5 g, 168 mmol) and phosphoryl chloride (50 mL) according to the general procedure Ia to d preparation of chlorides. Obtained as an off-white solid (53.4 g, 98%). MS (ISN) 384.1 [(M+OAc)−], 386.0 [(M+2+OAc)−]; mp 39-40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-4cef0875ee484f49922f2f30e12548af |
| Source note | uspto-grants-2010_01 |