Phosphorus oxybromide → HCID 57468627, compound

HRID 1989106Notes

Reaction equation

HRID 1989106 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:13][C:12](=O)[CH:11]=[C:10]([CH3:15])[CH:9]=2)=[CH:4][CH:3]=1.P(Br)(Br)([Br:18])=O>C1(C)C=CC=CC=1>[Br:18][C:12]1[CH:11]=[C:10]([CH3:15])[CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:13]=1

Participants

4

Reactant 2

HCID 24613Phosphorus oxybromideHCID 404694HCID 404694, compound

Product 1

HCID 57468627HCID 57468627, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The title compound was prepared from 6-(4-chloro-phenyl)-4-methyl-1H-pyridin-2-one (1.1 g, 5 mmol) and phosphoryl bromide (4.63 g, 16 mmol) in toluene (9.5 mL) according to the general procedure Ia to d preparation of bromides. Obtained as a light brown solid (1.0 g, quant., 74% purity). MS (ISP) 282.0 [(M+H)+], 284.0 [(M+2+H)+] and 286.0 [(M+4+H)+].

Workup

  1. customObtained as a light brown solid (1.0 g, quant., 74% purity)

Sources & evidence

ORD record
ord-1e1752f362214fdba2eaf04a2c01e77e
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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