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HRID1989112

反应详情

EQUATION

反应方程式

HRID 1989112 的结构方程式

REACTANTS

反应物

2
结构：O=P(Cl)(Cl)Cl
HCID24813

Phosphoric trichloride

Cl3OP

结构：Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(=O)[nH]1
HCID57468644

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(-c2ccc(C(F)(F)F)cc2)cc(Cl)n1
HCID57468643

2-Chloro-6-methyl-4-[4-(trifluoromethyl)phenyl]pyridine

C13H9ClF3N

PROCEDURE

实验过程

The title compound was prepared from 6-methyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (20 g, 79 mmol) and phosphoryl chloride (36.0 mL, 395 mmol) according to the general procedure Ia to d preparation of chlorides. Obtained as an off-white solid (17.35 g, 81%). NMR (DMSO-d6) δ 7.71 (s, 1H), 7.73 (s, 1H), 7.88 (d, 2H, J=8.1 Hz), 8.05 (d, 2H, J=8.1 Hz) ppm.