Phosphorus oxychloride → HCID 60209325, compound

HRID 1989116Notes

Reaction equation

HRID 1989116 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:15]2[NH:20][C:19](=O)[N:18]=[C:17]([C:22]([F:25])([F:24])[F:23])[CH:16]=2)[CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12].O=P(Cl)(Cl)[Cl:30]>>[Cl:30][C:19]1[N:20]=[C:15]([C:7]2[CH:8]=[CH:9][C:10]([C:11]([F:14])([F:13])[F:12])=[C:5]([O:4][CH2:3][C:2]([F:27])([F:26])[F:1])[CH:6]=2)[CH:16]=[C:17]([C:22]([F:25])([F:24])[F:23])[N:18]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517781HCID 178517781, compound

Product 1

HCID 60209325HCID 60209325, compound

Procedure

The title compound was prepared from 6-[3-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-4-trifluoromethyl-1H-pyrimidin-2-one (3.74 g, 9.21 mmol) and phosphoroxychloride (30 mL) according to the general procedure I. Obtained as a brown solid (3.75 g, 96%). MS (EI) 424.0 [(M)+]; mp 44° C.

Sources & evidence

ORD record
ord-5a95d469354343a2afe0e4db9a730e78
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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