Phosphorus oxychloride → HCID 57468665, compound

HRID 1989120Notes

Reaction equation

HRID 1989120 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[NH:11][C:10](=O)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.O=P(Cl)(Cl)[Cl:21]>>[Cl:21][C:10]1[N:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 574686664-(3-Chloro-phenyl)-6-trifluoromethyl-1h-pyrimidin-2-one

Product 1

HCID 57468665HCID 57468665, compound

Procedure

The title compound was prepared from 4-(3-chloro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (2.44 g, 8.88 mmol) and phosphoroxychloride (25 mL) according to the general procedure I. Obtained as a white solid (1.62 g, 62%). MS (EI) 292.0 [(M)+]; mp 89.5° C.

Sources & evidence

ORD record
ord-6b3a965e4eaf4a62b9f01d8fcda153d2
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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