Phosphorus oxychloride → HCID 57468667, compound

HRID 1989121Notes

Reaction equation

HRID 1989121 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[NH:11][C:10](=O)[N:9]=2)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:21]>>[Cl:21][C:10]1[N:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 120794664-(4-Fluorophenyl)-6-(trifluoromethyl)-2(1H)-pyrimidinone

Product 1

HCID 57468667HCID 57468667, compound

Procedure

The title compound was prepared from 4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (15.5 g, 0.06 mol) and phosphoroxychloride (155 mL) according to the general procedure I. Obtained as a light yellow solid (16.5 g, 99%). MS (EI) 276.1 [(M)+]; mp 67° C.

Sources & evidence

ORD record
ord-8dcbdd44d9684f3180769b8da00d9b85
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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