Phosphorus oxychloride → HCID 57468677, compound

HRID 1989126Notes

Reaction equation

HRID 1989126 reaction equation
[CH2:1]([C:3]1[NH:8][C:7](=O)[CH:6]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[CH:4]=1)[CH3:2].P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:7]1[CH:6]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[CH:4]=[C:3]([CH2:1][CH3:2])[N:8]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 57468678HCID 57468678, compound

Product 1

HCID 57468677HCID 57468677, compound

Procedure

The title compound was prepared from the above described 6-ethyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (4.6 g, 17.2 mmol) and phosphoryl chloride (7.85 mL, 86.1 mmol) according to the general procedure Ia to d preparation of chlorides. Obtained as a light yellow solid (2.2 g, 44%). MS (ISP) 286.1 [(M+H)+] and 288.0 [(M+2+H)+].

Sources & evidence

ORD record
ord-c83471a22ec04eaf9e94dd8dc8193a43
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

Loading…