Phosphorus oxychloride → 2-Chloro-4-(2-fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine

HRID 1989129Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[NH:15][C:14](=O)[N:13]=1.O=P(Cl)(Cl)[Cl:25]>>[Cl:25][C:14]1[N:13]=[C:12]([C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:7][C:2]=2[F:1])[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:15]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 574686894-(2-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-1h-pyrimidin-2-one

Product 1

HCID 574686882-Chloro-4-(2-fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 4-(2-fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (9.84 g, 0.03 mol) and phosphoroxychloride (50 ml) according to the general procedure I. Obtained as a light yellow solid (9.99 g, 96%). MS (ISN) 341.2 [(M−H)−]; mp 47° C.

Sources & evidence

ORD record: ord-0d53c43d9ea1496a9ab048a7d358b486
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07642264B2

Reaction notes

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