2-Chloro-6-methyl-4-(4-(trifluoromethyl)phenyl)pyridine → 2-(4-Iodo-imidazol-1-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1989155Notes

Reaction equation

HRID 1989155 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:18])[N:3]=1.[I:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[I:19][C:20]1[N:21]=[CH:22][N:23]([C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[CH:5]=[C:4]([CH3:18])[N:3]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 574686432-Chloro-6-methyl-4-(4-(trifluoromethyl)phenyl)pyridineHCID 178506559HCID 178506559, compound

Product 1

HCID 574687422-(4-Iodo-imidazol-1-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Procedure

The title compound was prepared 2-chloro-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine (example A.30) (1.0 g, 3.7 mmol) and commercially available 4-iodo-imidazole (0.857 g, 4.4 mmol) according to the general procedure IVa. Obtained as a yellow solid (0.98 g, 62%). MS (ISP) 430.2 [(M+H)+].

Sources & evidence

ORD record
ord-12f778b85c254413af6c8c9246875b04
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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