HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methyl-4-(4-(trifluoromethyl)phenyl)pyridine → 2-(4-Iodo-imidazol-1-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methyl-4-(4-(trifluoromethyl)phenyl)pyridine | HCID 57468643 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 2-(4-Iodo-imidazol-1-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57468742 | — |
Reaction Steps
The title compound was prepared 2-chloro-6-methyl-4-(4-trifluoromethyl-phenyl)pyridine (example A.30) (1.0 g, 3.7 mmol) and commercially available 4-iodo-imidazole (0.857 g, 4.4 mmol) according to the general procedure IVa. Obtained as a yellow solid (0.98 g, 62%). MS (ISP) 430.2 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-12f778b85c254413af6c8c9246875b04 |
| Source note | uspto-grants-2010_01 |