2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyridine → 4-(4-Chloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyridine

HRID 1989167Notes

Reaction equation

HRID 1989167 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:15])[N:3]=1.[I:16][C:17]1[N:18]=[CH:19][NH:20][CH:21]=1>>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[CH:5]=[C:4]([CH3:15])[N:3]=[C:2]([N:20]3[CH:21]=[C:17]([I:16])[N:18]=[CH:19]3)[CH:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 574686392-Chloro-4-(4-chloro-phenyl)-6-methyl-pyridineHCID 178506559HCID 178506559, compound

Product 1

HCID 574687494-(4-Chloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyridine

Procedure

The title compound was prepared 2-chloro-4-(4-chloro-phenyl)-6-methyl-pyridine (example A.27) (2.3 g, 10 mmol) and commercially available 4-iodo-imidazole (2.248 g, 12 mmol) according to the general procedure IVa. Obtained as an off-white solid (2.1 g, 55%). MS (ISP) 396.0 [(M+H)+].

Sources & evidence

ORD record
ord-3d8b72ec0b2242ed8eb996545d4844c7
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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