2-Chloropyridine-4-boronic acid → HCID 57468773, compound

HRID 1989191Notes

Reaction equation

HRID 1989191 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:3]=1.[Cl:22][C:23]1[CH:28]=[C:27](B(O)O)[CH:26]=[CH:25][N:24]=1>>[Cl:22][C:23]1[CH:28]=[C:27]([C:2]2[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[N:3]=2)[CH:26]=[CH:25][N:24]=1

Participants

3

Reactant 2

HCID 51515952-Chloropyridine-4-boronic acidHCID 57468661HCID 57468661, compound

Product 1

HCID 57468773HCID 57468773, compound

Procedure

The title compound was prepared from 2-chloro-4-trifluoromethyl-6-(3-trifluoromethylphenyl)-pyrimidine (example A.42) (0.65 g, 2.0 mmol) and commercially available 2-chloro-pyridine-4-boronic acid (0.35 g, 2.22 mmol) according to the general procedure IVb. Obtained as an off-white solid (0.59 g, 73%). MS (ISP) 404.0 [(M+H)+]; mp 147° C.

Sources & evidence

ORD record
ord-75f2324557d24cb88ee708222b91e316
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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