2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → 2-(4-Iodo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

HRID 1989203Notes

Reaction equation

HRID 1989203 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[I:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[I:19][C:20]1[N:21]=[CH:22][N:23]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 574686142-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidineHCID 178506559HCID 178506559, compound

Product 1

HCID 574687852-(4-Iodo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)pyrimidine (example A.12) (2.34 g, 8.58 mmol) and commercially available 4-iodo-imidazole (2.50 g, 12.9 mmol) according to the general procedure IVa. Obtained as a light brown solid (2.67 g, 72%). MS (ISP) 431.1 [(M+H)+]; mp 167° C.

Sources & evidence

ORD record
ord-d463adfa41284472b745c78996fd8375
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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