HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → 2-(4-Iodo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 57468614 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 2-(4-Iodo-imidazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 57468785 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)pyrimidine (example A.12) (2.34 g, 8.58 mmol) and commercially available 4-iodo-imidazole (2.50 g, 12.9 mmol) according to the general procedure IVa. Obtained as a light brown solid (2.67 g, 72%). MS (ISP) 431.1 [(M+H)+]; mp 167° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-d463adfa41284472b745c78996fd8375 |
| Source note | uspto-grants-2010_01 |