2-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine → 4-(3,4-Dichloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

HRID 1989206Notes

Reaction equation

HRID 1989206 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=1.[I:20][C:21]1[N:22]=[CH:23][NH:24][CH:25]=1>>[Cl:15][C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=[C:2]([N:24]3[CH:25]=[C:21]([I:20])[N:22]=[CH:23]3)[N:7]=2)[CH:13]=[CH:12][C:11]=1[Cl:14]

Participants

3

Reactant 2

HCID 154777402-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidineHCID 178506559HCID 178506559, compound

Product 1

HCID 574687884-(3,4-Dichloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-trifluoromethyl-pyrimidine (example A.7) (1.97 g, 6.0 mmol) and commercially available 4-iodo-imidazole (1.28 g, 6.6 mmol) according to the general procedure IVa. Obtained as an off-white solid (2.67 g, 92%). MS (ISP) 485.1 [(M+H)+]; mp 223° C.

Sources & evidence

ORD record
ord-dac8bdd407dc4750ba0a79296ad433d5
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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