2-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine → 4-(3,4-Difluoro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

HRID 1989210Notes

Reaction equation

HRID 1989210 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=2)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=1.[I:20][C:21]1[N:22]=[CH:23][NH:24][CH:25]=1>>[F:15][C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=[C:2]([N:24]3[CH:25]=[C:21]([I:20])[N:22]=[CH:23]3)[N:7]=2)[CH:13]=[CH:12][C:11]=1[F:14]

Participants

3

Reactant 2

HCID 574686682-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidineHCID 178506559HCID 178506559, compound

Product 1

HCID 574687924-(3,4-Difluoro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine (example A.46) (1.50 g, 5.1 mmol) and commercially available 4-iodo-imidazole (1.48 g, 7.63 mmol) according to the general procedure IVa. Obtained as a light red solid (2.23 g, 97%). MS (ISP) 452.9 [(M+H)+]; mp 206° C.

Sources & evidence

ORD record
ord-b66edb2c2eed4f0898838c6694c32ad4
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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