HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine → 4-(3,4-Difluoro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine | HCID 57468668 | — |
| Reactant | HCID 178506559 | HCID 178506559 | — |
| Product | 4-(3,4-Difluoro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine | HCID 57468792 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine (example A.46) (1.50 g, 5.1 mmol) and commercially available 4-iodo-imidazole (1.48 g, 7.63 mmol) according to the general procedure IVa. Obtained as a light red solid (2.23 g, 97%). MS (ISP) 452.9 [(M+H)+]; mp 206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-b66edb2c2eed4f0898838c6694c32ad4 |
| Source note | uspto-grants-2010_01 |