HCID 57468683, compound → 2'-Chloro-4-(3-methoxy-4-trifluoromethylphenyl)-6-methyl-[2,4']bipyridinyl

HRID 1989229Notes

Reaction equation

HRID 1989229 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH3:19])[N:16]=[C:15](OS(C(F)(F)F)(=O)=O)[CH:14]=2)[CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10].[Cl:28][C:29]1(B(O)O)[CH:34]=[CH:33][CH:32]=[CH:31][NH:30]1>>[Cl:28][C:29]1[CH:34]=[C:33]([C:15]2[CH:14]=[C:13]([C:5]3[CH:6]=[CH:7][C:8]([C:9]([F:12])([F:11])[F:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=[C:17]([CH3:19])[N:16]=2)[CH:32]=[CH:31][N:30]=1

Participants

3

Reactant 2

HCID 57468683HCID 57468683, compoundHCID 68828138HCID 68828138, compound

Product 1

HCID 866154482'-Chloro-4-(3-methoxy-4-trifluoromethylphenyl)-6-methyl-[2,4']bipyridinyl

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 4-(3-methoxy-4-trifluoromethyl-phenyl)-6-methyl-pyridin-2-yl ester (example A.59) (2.0 g, 5.0 mmol) and commercially available 2-chloropyridine boronic acid (0.758 g, 5.0 mmol) according to the general procedure IVb; Obtained as an off-white solid (1.50 g, 82%). MS (ISP) 379.2 [(M+H)+] and 381 [(M+2+H)+].

Sources & evidence

ORD record
ord-bf593444e2ff451384f9b339d3bcd265
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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