Pyrrole → HCID 57468848, compound

HRID 1989271Notes

Reaction equation

HRID 1989271 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[CH:5]=[C:4]([C:18]([F:21])([F:20])[F:19])[N:3]=1.[NH:22]1[CH:26]=[CH:25][CH:24]=[CH:23]1>>[N:22]1([C:2]2[N:3]=[C:4]([C:18]([F:21])([F:20])[F:19])[CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[N:7]=2)[CH:26]=[CH:25][CH:24]=[CH:23]1

Participants

3

Reactant 2

HCID 8027PyrroleHCID 574685992-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine

Product 1

HCID 57468848HCID 57468848, compound

Procedure

The title compound was prepared from 2-chloro-4-(4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine (example A.2) (0.16 g, 0.5 mmol) and commercially available pyrrole (0.067 g, 1.0 mmol) according to the general procedure IVa. Obtained as an off-white solid (0.04 g, 22%). MS (EI) 357.0 [(M)+]; mp 120.5° C.

Sources & evidence

ORD record
ord-b3b3ac21fceb496aa3f89b026d0d0cb3
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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