HRID19893

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)N1CCC(Oc2ccc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1

HCID11603838

未命名化合物

结构：O=C(c1cc2cc(OC3CCN(C4CCC4)CC3)ccc2n1-c1cncnc1)N1CCC(F)(F)CC1

HCID16739661

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc3[nH]c(C(=O)O)cc3c2)CC1.Cl

HCID67017922

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(Oc2ccc3[nH]c(C(=O)N4CCC(F)(F)CC4)cc3c2)CC1

HCID67017912

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for the synthesis of intermediate 1, step 4, the title compound was synthesized from 5-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloride salt with 1 eq. lithium chloride (example 43, step 4). The title compound was obtained in 59% yield as white solid. MS (m/e): 464.3 (MH+, 75%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ddc4b27a543441a58dca287c82b3147e
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745479B2
来源说明: uspto-grants-2010_06

反应 SMILES

[F:1][C:2]1([F:29])[CH2:7][CH2:6][N:5]([C:8]([C:10]2[NH:11][C:12]3[C:17]([CH:18]=2)=[CH:16][C:15]([O:19][CH:20]2[CH2:25][CH2:24][N:23](C(C)C)[CH2:22][CH2:21]2)=[CH:14][CH:13]=3)=[O:9])[CH2:4][CH2:3]1.Cl.[C:31]([O:35][C:36](N1CCC(OC2C=C3C(=CC=2)NC(C(O)=O)=C3)CC1)=[O:37])([CH3:34])([CH3:33])[CH3:32].C1(N2CCC(OC3C=C4C(=CC=3)N(C3C=NC=NC=3)C(C(N3CCC(F)(F)CC3)=O)=C4)CC2)CCC1>>[C:31]([O:35][C:36]([N:23]1[CH2:24][CH2:25][CH:20]([O:19][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[NH:11][C:10]([C:8]([N:5]2[CH2:6][CH2:7][C:2]([F:29])([F:1])[CH2:3][CH2:4]2)=[O:9])=[CH:18]3)[CH2:21][CH2:22]1)=[O:37])([CH3:34])([CH3:33])[CH3:32]