HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone → 4-[2-(4,4-Difluoro-piperidine-1-carbonyl)-1H-indol-5-yloxy]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Reactant | [5-(1-Cyclobutyl-piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 16739661 | — |
| Reactant | 5-(1-Tert-butoxycarbonyl-piperidin-4-yloxy)-1h-indole-2-carboxylic acid hydrochloride salt | HCID 67017922 | — |
| Product | 4-[2-(4,4-Difluoro-piperidine-1-carbonyl)-1H-indol-5-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 67017912 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of intermediate 1, step 4, the title compound was synthesized from 5-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid hydrochloride salt with 1 eq. lithium chloride (example 43, step 4). The title compound was obtained in 59% yield as white solid. MS (m/e): 464.3 (MH+, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-ddc4b27a543441a58dca287c82b3147e |
| Source note | uspto-grants-2010_06 |