HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutanone → 5-(1-Cyclobutyl-piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutanone | HCID 14496 | — |
| Reactant | 5-(Piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester | HCID 67017921 | — |
| Product | 5-(1-Cyclobutyl-piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester | HCID 67017902 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of example 43, step 7, the title compound was synthesized from 5-(piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester (example 44, step 2) and cyclobutanone. The title compound was obtained in 58% yield as light yellow solid. MS (m/e): 421.1 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-de48f38b6fee47caaefe5a4212650c77 |
| Source note | uspto-grants-2010_06 |