Hydrochloric Acid → HCID 68526899, compound

Participants

Reaction Steps

2N Sodium hydroxide (500 μl, 1 mmol) was added to a solution of methyl-6-amino-9-benzyl-8-methoxy-8,9-dihydro-7H-purine-2-carboxylate (Example 245) (100 mg, 0.32 mmol) in methanol (3 ml) and the reaction mixture stirred at room temperature for 2 hours. The solution was acidified to pH 2 with 2N hydrochloric acid and the resultant precipitate collected by filtration and washed with water. The solid was azeotroped with toluene and ether then dried in vacuo to yield the title compound (64 mg, 0.214 mmol).

Provenance & Evidence