Hydrochloric Acid → HCID 68526899, compound

HRID 1989802Notes

Reaction equation

HRID 1989802 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[N:15]=[C:14]2[C:10]([NH:11][CH:12]([O:23][CH3:24])[N:13]2[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([NH2:25])[N:8]=1)=[O:6].Cl>CO>[NH2:25][C:9]1[N:8]=[C:7]([C:5]([OH:6])=[O:4])[N:15]=[C:14]2[C:10]=1[NH:11][CH:12]([O:23][CH3:24])[N:13]2[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68525319HCID 68525319, compound

Product 1

HCID 68526899HCID 68526899, compoundYield 66.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2N Sodium hydroxide (500 μl, 1 mmol) was added to a solution of methyl-6-amino-9-benzyl-8-methoxy-8,9-dihydro-7H-purine-2-carboxylate (Example 245) (100 mg, 0.32 mmol) in methanol (3 ml) and the reaction mixture stirred at room temperature for 2 hours. The solution was acidified to pH 2 with 2N hydrochloric acid and the resultant precipitate collected by filtration and washed with water. The solid was azeotroped with toluene and ether then dried in vacuo to yield the title compound (64 mg, 0.214 mmol).

Workup

  1. filtrationthe resultant precipitate collected by filtration
  2. washwashed with water
  3. customThe solid was azeotroped with toluene and ether
  4. customthen dried in vacuo

Sources & evidence

ORD record
ord-c9994756423a4ad9ae02a486735ed19a
Source dataset
uspto-grants-2010_01
Patent number
US07642350B2

Reaction notes

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