Hydrochloric Acid → HCID 11977826, compound

HRID 1989807Notes

Reaction equation

HRID 1989807 reaction equation
[OH-].[Na+].[NH2:3][C:4]1[N:12]=[C:11]([C:13]([O:15]C)=[O:14])[N:10]=[C:9]2[C:5]=1[NH:6][C:7](=[O:24])[N:8]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Cl>CO>[NH2:3][C:4]1[N:12]=[C:11]([C:13]([OH:15])=[O:14])[N:10]=[C:9]2[C:5]=1[NH:6][C:7](=[O:24])[N:8]2[CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11977825HCID 11977825, compound

Product 1

HCID 11977826HCID 11977826, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2N Sodium hydroxide (64 ml, 128 mmol) was added to a solution of methyl 6-amino-9-benzyl-8-oxo-8,9-dihydro-7H-purine-2-carboxylate (7.66 g, 25.6 mmol) in methanol (100 ml) and the reaction mixture stirred at room temperature for 2 hours. The solution was acidified to pH 2 with 2N hydrochloric acid and the resultant precipitate collected by filtration and washed with water. The solid was azeotroped with toluene and ether then dried in vacuo to yield the title compound (7.3 g, 25.6 mmol, 100%).

Workup

  1. filtrationthe resultant precipitate collected by filtration
  2. washwashed with water
  3. customThe solid was azeotroped with toluene and ether
  4. customthen dried in vacuo

Sources & evidence

ORD record
ord-45e811bd24034e2282ca0651c5489c7f
Source dataset
uspto-grants-2010_01
Patent number
US07642350B2

Reaction notes

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